In 2025, Malaysia assumes the ASEAN Chairmanship for the fifth time, following a decade since its last term in 2015. This white paper, a collaborative initiative between SERI and the US-ASEAN Business Council (USABC), highlights five priority areas for Malaysia’s leadership: Digital Economy, Workforce Development, Healthcare, Sustainability, and Energy Transition. The paper calls for Malaysia to seize the moment to shape ASEAN’s future, address emerging challenges, and harness opportunities that will define the region’s trajectory.